Groupe Retinal degeneration and regeneration : Yvan Arsenijevic
Projets Retinal degeneration and regeneration | Annuaire | Publications | Collaboration | Alumni

Groupe From physiopathology of retinal diseases to clinical applications : Laura Kowalczuk
Projets From physiopathology of retinal diseases to clinical applications | Annuaire | Publications | Collaboration

Groupe Macular degeneration and diabetic retinopathy : Raphael Roduit
Projets Macular degeneration and diabetic retinopathy | Annuaire | Publications | Collaboration |

Groupe Retinal disorder research : Corinne Kostic
Projets Retinal disorder research | Annuaire | Publications | Collaboration |

Groupe Gestion / Secrétariat / Animalerie

Votre soutien


Groupe "Macular degeneration and diabetic retinopathy"

Publications - Numéro ORCID (0000-0001-7440-2799)

Pyakurel A., Balmer D., Saba El Leil M., Kizilyaprak C., Daraspe J., Humbel B., Le YZ., vonLintig J. Meloche S. and Roduit R. "Loss of ERK1/2 in the retinal pigment epithelium leads to RPE65 decrease and retinal degeneration." Molecular and Cellular Biology, 37:e00295-17. 2017

Balmer D. , Bapst-Wicht L. , Pyakurel A. , Emery M. , Nanchen N. , Bochet C.G. , Roduit R. "Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis." Frontiers in Aging Neuroscience 9:43. 2017.

Emery M., Nanchen N., Preitner F.,  Ibberson, M, and Roduit R. "Biological characterization of genes response to insulin-induced hypoglycemia in mouse retina." PLosONE 11(2): e0150266. 2016.

Mantel I., Ambresin A., Droz I., Roduit R., Faouzi M., Munier FL. and Schorderet D. "Complement Factor B Polymorphism and the Phenotype of Early Age-Related Macular Degeneration." Ophthalmics Genetics 35(1):12-7. 2014.

Balmer D., Andreux P., Auwerx J., Puyal J., Puyal-Guinet V., Schorderet D. and Roduit R. "Autophagy defects is associated with low glucose-induced apoptosis in 661W photoreceptor cells." PLosONE 8(9): e74162, 2013.

Métrailler S., Emery M., Schorderet D., Cottet S. and Roduit R. "Erk1/2 pathways is activated in degenerated RPE65-deficiente mice" Exp Eye res. 116C [Epub ahead of print] 2013.

Emery M., Schorderet DF. and Roduit R. "Acute Hypoglycemia Induces Retinal Cell Death in Mouse." PLosONE 6(6): e21586, 2011.

*Joly E., *Roduit R., Peyot M-L., Habinowski SA., Ruderman N.B., Witters L.A. and Prentki M. "Glucose represses PPARa gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic b-cell. " Journal of Diabetes 1 : 263-272, 2009. (*equal contribution)

Roduit R., Escher P. and Schorderet D. "Mutations in the DNA-Binding Domain of NR2E3 affect in vivo dimerization and interaction with CRX." PLosONE 4(10): e7379, 2009.

Escher P., Gouras P., Roduit R., Tiab L., Bolay S., Delarive T., Chen S., Tsai CC., Hayashi M., Zernant J., Merriam J E. , Mermod N., Allikmets R., Munier FL. and Schorderet DF. "Mutations in NR2E3 can cause dominant or recessive retinal degenerations in a same family." Hum Mutat. 30(3):342-51, 2009.

Roduit R. and Schorderet DF. "MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells." Apoptosis. 13(3): 343-53, 2008.

Meadler K., Bielmann C., Allaman-Pillet N., Beckman J., Bonny C., Donath M. and Roduit R. "Leptin and glucose induce b-cell apoptosis through activation of c-Jun N-terminal kinases (SAPK/JNK)." FASEB J.22: 1905-1913, 2008.

Guenat S., Rouleau N., Bielman C., Bedard J., Maurer F., Bonny C., Beckman J., Allaman-Pillet N., Nicod P., Bossé R. and Roduit R. "Homogenous and non-radioactive HTS platform for screening Kinase inhibitors in whole cells." J Biomol Screen. 11(8): 1015-26, 2006.

Kristensen O., Guenat S., Allaman-Pillet N., Dar I., Kastrup J.E., Roduit R., Beckman J., Gajhede M. and Bonny C. "Structural basis for an novel SH3 domain dimerization involving the canonical PPII recognition site." EMBO J. 25(4): 785-97, 2006.

*Gremlich S., *Nolan C., *Roduit R., Burcelin R. Peyot M-L. Delghingaro-Augusto V., Desvergne B., Michalik L., Prentki M. and Wahli W, "Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation." Endocrinology 146(1): 375-82. 2005. (*equal contribution)

Joly E,.Bendayan M., Roduit R., Saha A.K., Ruderman N.B. and Prentki M. "MalonylCoA Decarboxylase is present in the cytosolic, in the mitochondrial and the peroxisomal compartments of rat hepatocytes." FEBS letter. 579(29): 6581-6586, 2005.

Roduit R., Nolan C., Alarcón C., Kelpe C., Przybykowski E., Morin J., Massé F., Massie B., Ruderman N., Rhodes C.J. Poitout V. and Prentki M.. "A role for the Malonyl-CoA Decarboxylase/Long Chain Acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli." Diabetes 53:1007-1019, 2004.

Abdelli S., Ansite J., Roduit R., Borsello T., Matsumoto I., Sawada T., Allaman-Pillet N., Henry H., Beckmann J.S., Hering B. and Bonny C. "Intracellular Stress Signalling Pathways Activated During Human Islet Preparation And Following Acute Cytokine Attack." Diabetes 53: 2815-2823, 2004.

Allaman-Pillet N., Roduit R., Oberson A., Ruiz J., Schorderet DF. and Bonny C. "Circadian regulation of islet genes involved in insulin production and secretion." Molecular and Cellular Endocrinology 226: 59-66, 2004.

Allaman-Pillet N., Størling J., Oberson A., Roduit R., Negri S., Sauser C., Nicod P., Beckmann JS., Schorderet DF., Mandrup-Poulsen T. and Bonny C. "Calcium- and Proteasome-dependent Degradation of the JNK Scaffold Protein Islet-brain 1." J Biol. Chem. 278(49):48720-48726, 2003.

El-Assaad, W., Buteau, J., Peyot, ML., Hardy, S., Roduit R., Joly, E., Dbaibo, G., Rosenberg, L. and Prentki, M. "Elevated glucose and fatty acids synergized to causing b-cell death." Endocrinology 144: 4154-4163, 2003.

Wu Y., Han B., Luo H., Roduit R., Zhang J. and Wu J. "DcR3/TR6 Effectively prevents Islet Primary Nonfunction after Transplantation." Diabetes 52: 2279-2286, 2003.

Prentki M., Joly E., El-Assaad W. and Roduit R. "Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity: Role in beta-Cell Adaptation and Failure in the Etiology of Diabetes." Diabetes Suppl 3: S405-13, 2002.

Roh C., Roduit R., Thorens B., Fried S. and Kandror K.V. "Lipoprotein lipase and leptin are accumulated in different secretory compartments in rat adipocytes." J Biol. Chem. 276(38): 35990-35994, 2001.

*Roduit R., *Masiello P., *Wang S Li, H., Mitchell G. A. and Prentki M. "A role for hormone sensitive lipase in glucose-stimulated insulin secretion." Diabetes 50: 1970-1975, 2001.  (*equal contribution)

Prentki M., Roduit R., Corkey B.E., Lameloise N. and Assimacopoulos-Jeannet F. "Glucotoxicity, lipotoxicity and ß-cell function in diabetes : A role for altered lipid partitioning." Can J. Diabetes Care 25(1): 36-46, 2000.

Saha AK., Schwarsin AJ., Roduit R., Masse F., Kaushik V., Tornheim K., Prentki M. and Ruderman NB. "Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside." J. Biol. Chem. 275(32): 24279-83, 2000.

Roduit R., Morin J., Masse F., Segall L., Roche E., Newgard CB., Assimacopoulos-Jeannet F. and Prentki M. "Glucose down regulates the expression of the PPARa gene in the pancreatic b-cell."  J. Biol. Chem. 275(46): 35799-06, 2000.

Buteau J., Roduit R. and Prentki M.  "GLP-1 promotes DNA synthesis, activates PI3-kinase and increases pdx-1 DNA binding activity in b(ins-1)-cells."  Diabetologia  42(7): 856-854, 1999.

Voilley N., Roduit R., Vicaretti R., Bonny C., Waeber G., Dyck J.R.B., Lopaschuk G.D. and Prentki M. "Cloning and expression of rat pancreatic b-cell malonyl-CoA decarboxylase." Biochem. J. 340(1): 213-217, 1999.

Pralong F.P., Roduit R., Waeber G., Mosimann F., Rey F., Thorens B. and Gaillard R.C. "Evidence that leptin participates in the regulation of glucocorticoid production by the adrenal gland." Endocrinology. 139(10): 4264-4268, 1998.

Bonny C., Roduit R., Gremlich S., Nicod P., Thorens B. and Waeber G. "The loss of GLUT2 expression in the pancreatic beta-cells of diabetic db/db mice is associated with an impaired DNA-binding activity of islet-specific trans-acting factors." Mol. Cell Endocrinol. 135(1):59-65, 1997.

Gremlich S., Roduit R. and Thorens B. "Dexamethasone induces posttranslational degradation of GLUT2 and inhibition of insulin secretion in isolated pancreatic beta cells. Comparison with the effects of fatty acids." J Biol. Chem. 272(6):3216-3222, 1997.

Waeber G., Calandra T., Roduit R., Haefliger J-A., Bonny C., Thompson N., Thorens B., Temler E., Meinhardt A., Bacher M., Metz C.N., Nicod P. and Bucala R. "Insulin secretion is regulated by the glucose-dependent production of islets b-cell macrophage migration inhibitory factor." Proc. Natl. Acad. Sci. USA 94: 4782-4787, 1997.

Roduit R. and Thorens B. "Inhibition of insulin secretion by long-term exposure of pancreatic islets to leptin." FEBS letter. 415(2): 179-182, 1997.

Thorens B. and Roduit R. "Regulated expression of GLUT2 in diabetes studied in transplanted pancreatic beta cells." Biochem Soc Trans. 22(3):684-7, 1994.

Book chapters

Roduit R., Balmer D., Ibberson M. and Schorderet D.F. "Hypoglycemia and retinal cell death.", in Handbook of Nutrition, Diet and Eye, Ed. Victor R. Preedy, Elsevier, 2014.

Roduit R. and Schorderet DF. "Ischémie et atteinte neuronale: Apoptose. ", in Pathologies vasculaires oculaires, Ed. C Pournaras. Masson, Masson, Issy-les Moulinaeaux, 2008.

Allaman-Pillet N., Roduit R., Produit-Zengaffinen N. and Schorderet DF. "Perspectives thérapeutiques : modulation de l'apoptose à l'aide de peptides intracellulaire." in Pathologies vasculaires oculaires, Ed. C Pournaras. Masson, Masson, Issy-les Moulinaeaux, 2008.

Pôle de recherche fondamentale

Fondation Asile des aveugles
 av. de France 15, CP 5143
1002 Lausanne

Tél. :  +41 21 626 81 11
Fax : +41 21 626 88 88

Email :

Fondation Asile des aveugles - Avenue de France 15 - Case Postale 5143 - 1002 Lausanne - T +41 21 626 81 11 - F +41 21 626 88 88 - Dons: CCP 10-2707-0